百两金素 T3S2325
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 23643-61-0 | ¥372.00 | 询底价 |
1 mL | 23643-61-0 | ¥1,590.00 | 询底价 |
10 mg | 23643-61-0 | ¥1,390.00 | 询底价 |
25 mg | 23643-61-0 | ¥2,380.00 | 询底价 |
50 mg | 23643-61-0 | ¥3,530.00 | 询底价 |
100 mg | 23643-61-0 | ¥4,930.00 | 询底价 |
5 mg | 23643-61-0 | ¥955.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Ardisiacrispin A
描述: Ardisiacrispin A (Deglucocyclamin) 是一种常见的三萜皂苷,来自于紫金牛属物种。 它与来自紫金牛属的 A. crenata 中的一些三萜皂苷具有相似的生物学特性,如对肿瘤细胞具有细胞毒活性、免疫调节和抗病毒活性。
体外活性: Ardisiacrispin A+Ardisiacrispin B is a mixture of Ardisiacrispin A and ardisiacrispin B, derived from Ardisia crenata with a fixed proportion (2:1). METHODS AND RESULTS:The present study was conducted to investigate its anticancer activity on human cancer cells and its underlying mechanism of action. The (IC50)s of Ardisiacrispin A+Ardisiacrispin B on proliferation of several human cancer cell lines were in the range of 0.9-6.5 microg/ml by sulphorhodamine B-based colorimetric assay, in which Bel-7402 was the most sensitive cell line. Moreover, Ardisiacrispin A+Ardisiacrispin B induced dose-dependent apoptosis in Bel-7402 cells at doses of 1-10 microg/ml by flow cytometry, and resulted in the changes of the mitochondrial membrane depolarization, membrane permeability enhancement, and nuclear condensation in a dose-dependent manner through high-content screening analysis. Furthermore, Ardisiacrispin A+Ardisiacrispin B could disassemble microtubule in Bel-7402 cells; the fluorescence intensity of microtubules decreased at the concentration of 5-20 microg/ml. CONCLUSIONS: These findings suggest that Ardisiacrispin A+Ardisiacrispin B could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10.61 mg/mL (10 mM)
关键字: Inhibitor | LTS 4 | inhibit | LTS4 | Ardisiacrispin A
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相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Human Metabolite Library | Anti-virus Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Covalent Inhibitor Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途