BMS-1166-N-piperidine-COOH T40110

Product Introduction
Bioactivity


英文名: BMS-1166-N-piperidine-COOH

描述: BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1/PD-L1 degrader-1, which facilitates the degradation of PD-1/PD-L1. BMS-1166 demonstrates potent inhibition of PD-1/PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1/PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: BMS 1166 N piperidine COOH | BMS-1166-N-piperidine-COOH | BMS1166NpiperidineCOOH

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途