化合物ML329 T4028

Product Introduction
Bioactivity


英文名: ML329

描述: ML329 是小眼畸形相关转录因子抑制剂，它抑制 TRPM-1 启动子活性(IC50:1.2 μM)。

体外活性: ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. ML329 is a useful tool compound in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 31 mg/mL


关键字: ML329 | ML-329 | Inhibitor | ML 329 | inhibit

相关产品: AP 18 | TRPM8 antagonist WS-3 | JC-229 | Palvanil | ML204 | TRPM8 antagonist 2 | cim0216 | Hydroxy-α-sanshool | AMG-0347 | ABT-239

相关库: Ion Channel Inhibitor Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途