澳洲茄边碱 T4034
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 20311-51-7 | ¥1,490.00 | 询底价 |
5 mg | 20311-51-7 | ¥936.00 | 询底价 |
1 mL | 20311-51-7 | ¥1,420.00 | 询底价 |
25 mg | 20311-51-7 | ¥2,960.00 | 询底价 |
1 mg | 20311-51-7 | ¥453.00 | 询底价 |
50 mg | 20311-51-7 | ¥4,370.00 | 询底价 |
100 mg | 20311-51-7 | ¥6,230.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Solamargine
描述: Solamargine (δ-Solanigrine) 是一种来源于茄属植物的类固醇 Solasodine 的衍生物,诱导非选择性细胞毒性和 P-gp 抑制作用。它通过下调 MMP-2 和 MMP-9 的表达和活性来显著抑制 HepG2 细胞的迁移和侵袭,在多种癌症中均表现出抗癌活性。
体外活性: Solamargine concentration-dependently reduced HepG2 cell viability. Solamargine (7.5 μM) reduced cell viability by less than 20% in HepG2 cells. Solamargine (highest dose) decreased cell invasion and migration by more than 72% and 70% in HepG2 cells, respectively. Solamargine reduced function and expression of MMP-2/9 proteins. Solamargine time-dependently increased phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in a fashion.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 91 mg/mL(104.8 mM)
关键字: Apoptosis | Inhibitor | cytotoxicity | cells | Cluster of differentiation 243 | MDR1 | Pgp | P-glycoprotein | ABCB1 | inhibit | Solamargine | cancer | gastric | delta-Solanigrine | Multidrug resistance protein 1 | P-gp | CD243 | HepG2
相关产品: Inecalcitol | HYPOCRELLIN B | Quisinostat | MitoBloCK-6 | 14-Deoxyandrographolide | Tofacitinib | PI-273 | BMS-202 | Immunosuppressant-1 | Mitotane
相关库: Ion Channel Inhibitor Library | Anti-Liver Cancer Compound Library | Membrane Protein-targeted Compound Library | Human Metabolite Library | Kinase Inhibitor Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途