Mipomersen sodium T40727

Product Introduction
Bioactivity


英文名: Mipomersen sodium

描述: Mipomersen (sodium), a second-generation, 20-base phosphorothioate antisense oligonucleotide (ASO), targets human apoB-100.

体外活性: Mipomersen predominantly distributes to the liver and decreases the production of apoB-100, the primary structural protein of the atherogenic lipoproteins including low density lipoprotein (LDL), thereby reducing plasma LDL-cholesterol and apoB-100 concentrations[2]. Apolipoprotein (apo) B, a large amphipathic protein, plays a fundamental role in human lipoprotein metabolism. ApoB-100 is also a ligand for LDL receptor-mediated endocytosis of LDL by cells[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Mipomersen sodium

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途