XJB-5-131 T40979

Product Introduction
Bioactivity


英文名: XJB-5-131

描述: XJB-5-131 is a synthetic, bi-functional antioxidant specifically designed to target mitochondria for the scavenging of reactive oxygen species (ROS) and electrons, thereby acting as a radical scavenger. Additionally, it serves as an effective protector and mitigator against ionizing irradiation for cord blood mononuclear cells (CB MNCs).

体外活性: XJB-5-131 also ameliorates hemorrhagic shock (HS)-induced activation of the pro-apoptotic enzymes, caspases 3 and 7, in ileal mucosa[1]. XJB-5-131 reduces apoptosis and enhances cell survival in mouse embryonic cells?in vitro[2]. XJB-5-131 is a radiation protector for colony-forming unit-granulocyte macrophage (CFU-GM). XJB-5-131 is an effective mitigator when added after irradiation[3]. Cell Viability Assay[3]Cell Line: Low density mononuclear cells (MNC) Concentration: 10 μM Incubation Time: Added to cells one hour before irradiation or immediately after irradiation Result: Was a protector when given before irradiation as shown by an increase in the D0?to 1.93±0.13 for CFU-GM with XJB-5-131.

体内活性: XJB-5-131 ameliorates peroxidation of the mitochondrial phospholipid, cardiolipin, in ileal mucosal samples from rats subjected to hemorrhagic shock (HS)[1]. Intravenous treatment with XJB-5-131 (2 μmol/kg) significantly prolongs the survival of rats subjected to profound blood loss (33.5 mL/kg) despite administration of only a minimal volume of crystalloid solution (2.8 mL/kg) and the absence of blood transfusion[1]. XJB-5-131 reduces oxidative damage to mitochondrial DNA, maintains mitochondrial DNA copy number, suppresses motor decline and weight loss, enhances neuronal survival, and improves mitochondrial function. XJB-5-131 significantly suppresses the disease phenotypes and improves mitochondrial function in a mouse model of Huntington’s disease (HD)[2]. XJB-5-131 (1 mg/kg; intraperitoneally injected; three times a week up to 57 weeks) suppresses decline of weight loss and motor function in a mouse model of HD[2]. Animal Model: Male specific pathogen-free Sprague-Dawley rats, weighing 150 to 250 g[1]Dosage: 2 μmol/kg Administration: Administered intravenously using a syringe pump Result: The rats treated with XJB-5-131 survived significantly longer (P?< 0.01). Three of six survived for longer than 3 hours after completion of the hemorrhage protocol and one rat survived for the whole 6 hours postbleeding observation period. Animal Model: HD150KI mice[2]Dosage: 1 mg/kg Administration: Intraperitoneally injected; three times a week up to 57 weeks Result: Chronic treatment suppressed weight loss. Increased the average body mass by 22%.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: XJB5131 | XJB 5 131 | XJB-5-131

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途