HXR9 T41062

Product Introduction
Bioactivity


英文名: HXR9

描述: HXR9 is a cell-permeable peptide that acts as a competitive antagonist of the HOX/PBX interaction. It effectively inhibits the binding between HOX proteins and the transcription factor PBX, specifically in paralogue groups 1 to 8. HXR9 selectively impairs cell proliferation and induces apoptosis in cells with a high expression of the HOXA/PBX3 genes, for instance, MLL-rearranged leukemic cells.

体外活性: HXR9 (60μM; 4 hours) blocks the interaction between PBX and HOX[1]. HXR9 (60μM; 2 hours) triggers apoptosis in B16 and primary melanoma cells[1]. HXR9 (60μM; 2 hours) causes specific transcriptional changes[1]. HXR9 (B16 cells) shows antiproliferative activity with an IC 50 of 20μM[1]. Western Blot Analysis Cell Line: murine B16melanoma cells Concentration: 60 μM Incubation Time: 4 hours Result: Blocked the binding of HOXD9 to PBX. Apoptosis Analysis Cell Line: B16 cells Concentration: 60 μM Incubation Time: 2 hours Result: A significant proportion of cells were in late phases of apoptosis. RT-PCR Cell Line: B16F10cells Concentration: 60 μM Incubation Time: 2 hours Result: Fos , Jun , Dusp1 , and Atf1 ，were allsignificantly up-regulate.

体内活性: HXR9 (10 mg/kg; i.v. via the tail vein; twice weekly) blocks tumor growth[1]. HXR9 (Initial dose of 100?mg/kg (subsequent dosing of 10?mg/kg twice weekly);Intraperitoneal; twice weekly for 18 days) blocks A549 tumour growth in vivo[3]. Animal Model: C57black/6 mice (bearing B16 cells) Dosage: 10 mg/kg Administration: I.v. via the tail vein; twice weekly (~30 days) Result: Tumors showed a significant degree of growth retardation. Animal Model: Athymic nude mice (bearing A549 cells) Dosage: Initial dose of 100?mg/kg (subsequent dosing of 10?mg/kg twice weekly) Administration: Intraperitoneal; twice weekly for 18 days Result: The tumours of HXR9-treated mice were considerably smaller than those of the control groups.

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: HXR-9 | HXR9 | HXR 9

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途