化合物Anavex 2-73 T4111

Product Introduction
Bioactivity


英文名: Blarcamesine hydrochloride

描述: Blarcamesine hydrochloride (AVex-73 hydrochloride) 是一个sigma-1受体激动剂，IC50值为 860 nM。

动物实验: Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5?mg/mL.Male mice aged 7-9 weeks and weighing 32±2?g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100?μL/20?g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures.

体内活性: The pretreatment of Anavex 2-73 (1/3 mg/kg) dose-dependently reduces the scopolamine-induced alternation deficit. The pretreatment with Anavex 2-73 (>0.3 mg/kg) dose-dependently and significantly attenuates the impairments of step-through latency[1]. The Anavex 2-73 (1?mg/kg) dose-dependently blocks the recognition memory deficit. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Anavex 2-73 (0.1/1?mg/kg). Seven days after injections, Anavex 2-73 attenuates the decrease in Ser9 phosphorylation induced by the peptide (0.3/1?mg/kg)[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 37.5 mg/mL


关键字: AE37 Hydrochloride | AE-37 Hydrochloride | Inhibitor | AVex-73 Hydrochloride | Blarcamesine | Blarcamesine hydrochloride | Blarcamesine Hydrochloride | inhibit | AE 37 Hydrochloride | Sigma Receptor

相关产品: BD1063 dhydrochloride | 4-IBP | PD 144418 | KSK67 | Ditolylguanidine | AD186 | S1R agonist 2 hydrochloride | Sigma-1 receptor antagonist 1 | AB21 HCl | Siramesine hydrochloride

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Anti-Cancer Clinical Compound Library | NO PAINS Compound Library | Bioactive Compound Library

化合物Anavex 2-73 T4111信息由TargetMol中国为您提供，如您想了解更多关于化合物Anavex 2-73 T4111报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途