化合物ZLN 024 hydrochloride T41162
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 1883548-91-1 | ¥1,560.00 | 询底价 |
10 mg | 1883548-91-1 | ¥753.00 | 询底价 |
50 mg | 1883548-91-1 | ¥2,730.00 | 询底价 |
5 mg | 1883548-91-1 | ¥446.00 | 询底价 |
1 mg | 1883548-91-1 | ¥198.00 | 询底价 |
500 mg | 1883548-91-1 | ¥8,460.00 | 询底价 |
2 mg | 1883548-91-1 | ¥278.00 | 询底价 |
1 mL | 1883548-91-1 | ¥489.00 | 询底价 |
100 mg | 1883548-91-1 | ¥3,980.00 | 询底价 |
Product Introduction
Bioactivity
英文名: ZLN 024 hydrochloride
描述: ZLN 024 hydrochloride 是一种 AMPK 变构激活剂,可刺激无活性的 α1 亚基截短 α1 (1-394) 和 α1 (1-335),但不刺激 α1 (1-312)。
体外活性: ZLN 024 hydrochloride increases the activity of α1β1γ1 by 1.5-fold and has an EC50 of 0.42 µM, and it increases the activity of α2β1γ1 by 1.7-fold with an EC50 of 0.95 µM. ZLN 024 hydrochloride also directly activates recombinant AMPK α1β2γ1, by 1.7-fold with an EC50 of 1.1 µM; and AMPK α2β2γ1, by 1.6-fold with an EC50 of 0.13 µM. ZLN 024 hydrochloride directly activates recombinant AMPK α1β1γ1 and its homolog α2β1γ1 in a concentration-dependent manner[1].
体内活性: In C57BKS db/db mice, ZLN 024 hydrochloride(15 mg/kg/day; oral) improves glucose tolerance after 4 weeks of treatment. ZLN 024 hydrochloride reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content a
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (124.42 mM)
H2O : < 0.1 mg/mL (insoluble)
关键字: Inhibitor | AMP-activated protein kinase | ZLN-024 | ZLN 024 hydrochloride | inhibit | ZLN 024 Hydrochloride | ZLN-024 Hydrochloride | ZLN024 | ZLN 024 | ZLN024 Hydrochloride | AMPK
相关产品: Marein | Glycycoumarin | Pomolic acid | Nootkatone | WZ4003 | AMPK-IN-3 | Saponarin | Nepodin | Methyl cinnamate | GSK621
相关库: Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Glycolysis Compound Library | Bioactive Compound Library
化合物ZLN 024 hydrochloride T41162信息由TargetMol中国为您提供,如您想了解更多关于化合物ZLN 024 hydrochloride T41162报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途