醋酸奥曲肽 T4119
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 79517-01-4 | ¥413.00 | 询底价 |
200 mg | 79517-01-4 | ¥1,980.00 | 询底价 |
25 mg | 79517-01-4 | ¥618.00 | 询底价 |
50 mg | 79517-01-4 | ¥897.00 | 询底价 |
1 mL | 79517-01-4 | ¥490.00 | 询底价 |
5 mg | 79517-01-4 | ¥242.00 | 询底价 |
100 mg | 79517-01-4 | ¥1,370.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Octreotide Acetate
描述: Octreotide Acetate (Sandostatin) 是一种长期有效的合成生长抑素八肽类似物,可抑制生长激素的分泌。
动物实验: Octreotide (acetate) is formulated in saline.MiceThirty mice with HCC xenografts are randomLy divided into three groups: (A) Octreotide-soln group, (B) Octreotide-PPSG group, and (C) control group. Octreotide-soln group receives i.p. injection of 100 μg/kg octreotide-soln once a day and totally for consecutive 14 days. Octreotide-PPSG group receives a single subcutaneous injection of 1.4 mg/kg Octreotide-PPSG, and the injection volume is about 0.2 mL. Control group receives i.p. injection of saline once a day for consecutive 14 days. Treatment starts on the next day after injection of H22 hepatoma cell suspension and maintains for 14 days. Tumor growth is monitored by periodic caliper measurements on day 7 and day 14 post seeding. Tumor volumes (V) are calculated based on the length and width of tumor by Eq. RatTwelve male SD rats are divided into two groups, and housed in standard cages at 25°C, with free access to food and water for a week prior to the experiment. Rats are subcutaneously injected with Octreotidereotide solution (Octreotide-soln) or Octreotide-PPSG at an equivalent single dose of 20 mg/kg. The dose is determined based on the clinical dose of Octreotide-soln in human. Rats are fasted for 12 h before dosing and food is returned approximately 2 h post dosing. Blood samples are collected at predetermined time points using heparinized Eppendorf tubes. Immediately after collection, the blood samples are placed on ice until centrifuged at 3000 g for 10 min within 1 h. The plasma is collected and stored at ?20°C until analysis.
体内活性: Octreotide-treated groups show a significant reduction in the tumor volume compared to the saline group. Octreotide-PPSG (1.4 mg/kg, i.p.) shows greater antitumor effect than Octreotide-soln (100 μg/kg, i.p.). Octreotide-treatments results in significant inhibitory effect on the expression levels of SSTR2 and SSTR5 in primary HCC-bearing rats compared with the saline group. Octreotide-PPSG appears to inhibit the expression of SSTR2 and SSTR5 to a greater extent than that of Octreotide-soln treated group. A test dose of octreotide acetate significantly decreases the serum gastrin level to approximately one third of the baseline in 2 hr and the effect lasted approximately for 6 hr. On day 21, treatment with sustained-release formulation of octreotide acetatea (5 mg intramuscular, q 4 wk) is initiated.
存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 29 mg/mL
关键字: inhibit | Octreotide | SMS-201995 | SMS201995 | Inhibitor | SSTR | Somatostatin Receptor | SSTRs | Octreotide Acetate | SMS 201-995
相关产品: Cortistatin-14 acetate | Somatostatin 1-28 acetate | Pasireotide Acetate | Paltusotine | L-796,778 acetate | Seglitide acetate | Cyclosomatostatin Acetate | L-803087 | Cortistatin 14, human, rat acetate | (1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid
相关库: JAK-STAT Compound Library | Cyclic Peptide Library | Macrocyclic Compound Library | Peptide Compound Library | Preclinical Compound Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途