大花淫羊藿苷 A T4124

Product Introduction
Bioactivity


英文名: IKarisoside A

描述: IKarisoside A(Baohuoside II) 是一种来自小檗科植物淫羊藿的黄酮醇糖苷，具有抗炎活性。

体外活性: Ikarisoside A is a natural flavonol glycoside derived from plants of the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. We found that Ikarisoside A (1-100 μM) concentration-dependently inhibited the secretion of catecholamines induced by acetylcholine, a physiological secretagogue and agonist of nicotinic acetylcholine receptors. Ikarisoside A had little effect on catecholamine secretion induced by veratridine and 56 mM K(+). Ikarisoside A (1-100 μM) also inhibited (22)Na(+) influx and (45)Ca(2+) influx induced by acetylcholine in a concentration-dependent manner similar to that of catecholamine secretion. In Xenopus oocytes expressing α3β4 nicotinic acetylcholine receptors, Ikarisoside A (0.1-100 μM) directly inhibited the current evoked by acetylcholine. It also suppressed (14)C-catecholamine synthesis and tyrosine hydroxylase activity induced by acetylcholine at 1-100 μM and 10-100 μM, respectively. The present findings suggest that Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppression of nicotinic acetylcholine receptor-ion channels in bovine adrenal medullary cells.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/ml(228 mM)
Ethanol : 1 mg/ml(1.77 mM)


关键字: IKarisoside A

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相关库: Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library

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