化合物UCPH101 T4138

Product Introduction
Bioactivity


英文名: UCPH-101

描述: UCPH-101 是一种兴奋性氨基酸转运子亚型 1 (EAAT1) 的抑制剂(IC50:0.66 μM)。

体外活性: A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048). UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10.6 mg/mL(25 mM)


关键字: inhibit | UCPH101 | Inhibitor | UCPH-101

相关产品: Gentianine | Procyanidin A2 | Dodoviscin I | EAAT2 activator 1 | KL-11743 | SW157765 | Jujuboside A | Dodoviscin H | Nepodin | Homoeriodictyol

相关库: Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Metabolism Compound Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library | Bioactive Compound Library

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