化合物BPR1J-097 hydrochloride T4261

Product Introduction
Bioactivity


英文名: BPR1J-097 hydrochloride (1327167-19-0(free base))

描述: BPR1J-097 hydrochloride (1327167-19-0(free base)) 是一种新型小分子 FLT-3抑制剂(IC50=11±7 nM)，具有很好的体内抗肿瘤活性。

激酶实验: Cells are treated with THZ531 for 6 hours.After treatment cells are washed 2-fold with cold PBS and then lysed in the following lysis buffer: Hepes(50 mM, pH 7.4), NaCl（150 mM）, 1% Nonidet P40 substitute, EDTA（5 mM）, DTT（1 mM）, and protease/phosphatase cocktails.Lysates are treated with bio-THZ1 or bio-TH531 for pulldown overnight at 4°C.

体内活性: In FLT3-driven AML murine xenograft models, BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells and pronounced dose-dependent tumour growth inhibition and regression.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5.53 mg/mL (10 mM)


关键字: BPR1J 097 hydrochloride (1327167 19 0(free base)) | BPR1J-097 hydrochloride (1327167-19-0(free base)) | BPR-1J-097 hydrochloride (1327167-19-0(free base)) | BPR1J097 hydrochloride (1327167190(free base))

相关产品: BRD7389 | BPR1K871 | KW-2449 | TCS 359 | NVP-AEW541 | TG-89 | FLT3-IN-3 | UNC2025 2HCl (1429881-91-3(free base)) | Tyrphostin AG1296 | R406

相关库: Anti-Cancer Compound Library | Angiogenesis related Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

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