化合物Fmoc-Val-Ala-PAB T4286
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1394238-91-5 | ¥485.00 | 询底价 |
100 mg | 1394238-91-5 | ¥731.00 | 询底价 |
25 mg | 1394238-91-5 | ¥345.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Fmoc-Val-Ala-PAB-OH
描述: Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) 是一种有用的接头,可用于制备用于靶向药物递送的抗体-药物偶联物。它还用于合成带有溶酶体可切割接头的 RGD 拟肽-紫杉醇缀合物。
体内活性: Osilodrostat and pasireotide monotherapies can significantly affect in the histology and mean weights of the pituitary and adrenal glands, liver, and ovary/oviduct. Osilodrostat is associated with adrenocortical hypertrophy and hepatocellular hypertrophy. The combination of Osilodrostat with pasireotide ameliorates the liver and adrenal gland changes observed with monotherapy and does not exacerbate any target organ changes. Cmax and AUC(0–24h) of Osilodrostat and pasireotide increase in an approximately dose-proportional manner. Osilodrostat treatment reduces urinary free cortisol in patients with Cushing's disease; 78.9% has normal urinary free cortisol at week 22.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10 mM
关键字: Inhibitor | Antibody-drug conjugates linkers | ADC Linkers | Fmoc Val Ala PAB OH | Fmoc-Val-Ala-PAB-OH | inhibit | FmocValAlaPABOH
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相关库: Anti-COVID-19 Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途