化合物VAS2870 T4359

Product Introduction
Bioactivity


英文名: VAS2870

描述: VAS2870 是一种NADPH 氧化酶抑制剂。

体外活性: VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits the proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells. VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Moreover, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 83.3 mg/mL (231.14 mM)


关键字: NADPH Oxidase | VAS2870 | NOX | inhibit | VAS 2870 | VAS-2870 | Inhibitor

相关产品: Dehydroglyasperin C | NAD+ | KL1333 | GLX351322 | Setanaxib | Diphenyleneiodonium chloride | S19-1035 | Obafistat | NQO1 substrate | Triclosan

相关库: Anti-Aging Compound Library | Glutamine Metabolism Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Human Metabolite Library | Inhibitor Library | Target-Focused Phenotypic Screening Library | Preclinical Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途