化合物GSK-J4 Hydrochloride T4383
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 1797983-09-5 | ¥1,090.00 | 询底价 |
100 mg | 1797983-09-5 | ¥4,790.00 | 询底价 |
1 mg | 1797983-09-5 | ¥266.00 | 询底价 |
50 mg | 1797983-09-5 | ¥3,730.00 | 询底价 |
10 mg | 1797983-09-5 | ¥955.00 | 询底价 |
25 mg | 1797983-09-5 | ¥1,960.00 | 询底价 |
200 mg | 1797983-09-5 | ¥6,590.00 | 询底价 |
5 mg | 1797983-09-5 | ¥622.00 | 询底价 |
2 mg | 1797983-09-5 | ¥378.00 | 询底价 |
Product Introduction
Bioactivity
英文名: GSK-J4 Hydrochloride
描述: GSK-J4 Hydrochloride (GSK J4 HCl) 是 H3K27me3/me2 去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 双抑制剂,IC50分别为 8.6 和 6.6 μM。它是 GSK-J1 的乙酯衍生物,体外 IC50 值大于 50 μM。它抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α,IC50值为 9 μM。
体外活性: 当GSK-J4被施用于人类原代巨噬细胞时,可以减少LPS诱导的促炎细胞因子产量,尤其是显著降低TNFα的产量(IC50 = 9 μM)。
体内活性: Acting as a prodrug, GSK-J4 is rapidly hydrolyzed in cells to the otherwise cell impermeable GSK-J1, which exhibits an IC50 value of 60 nM for the purified enzyme. The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 20 mg/mL
DMSO : 50 mg/mL (110.14 mM)
关键字: Histone Demethylase | diabetic | Th17 | mice | cells | inflammation | Th1 | H3K27me3/me2 | dendritic | GSKJ4 Hydrochloride | TGF-β | 1373423-53-0 | inhibit | GSK-J4 Hydrochloride | 1373423-53-0 free base | Inhibitor | GSK J4 Hydrochloride | demethylase | GSK-J4 | GSK-J-4 Hydrochloride
相关产品: PBIT | LSD1-IN-6 | KDM5-C49 HCl | GSK-LSD1 | LSD1-IN-5 | CP2 | GSK J5 | CPI-455 | GSK2879552 | (rel)-Tranylcypromine D5 hydrochloride
相关库: Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Stem Cell Differentiation Compound Library | Methylation Compound Library | Histone Modification Compound Library | NO PAINS Compound Library | Bioactive Compound Library | Chromatin Modification Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途