西达本胺 T4481

Product Introduction
Bioactivity


英文名: Tucidinostat

描述: Tucidinostat (Chidamide) 是一种可口服的 HDAC I 类 HDAC1/2/3和第 IIb 类 HDAC10的抑制剂，IC50值分别为 95、160、67 和 78 nM。

体外活性: Tucidinostat shows potent antitumor activity and inhibits several human-derived tumour cell lines, such as HL-60, U2OS, LNCaP with GI50s of 0.4 ± 0.1, 2.0 ± 0.6, and 4.0 ± 1.2 μM, respectively. In addition, Tucidinostat shows less toxic to normal cells from human fetal kidney (CCC-HEK) and liver (CCCHEL)[1].

体内活性: Tucidinostat (12.5-50 mg/kg, p.o.) dose-dependently reduces tumour size and tumour weight in mice bearing HCT-8 colorectal carcinoma, A549 lung carcinoma, BEL-7402 liver carcinoma, and MCF-7 breast carcinoma, and with no obvious body loss[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
5% DMSO+95% Saline : 2.5 mg/mL (6.4 mM, suspension)
DMSO : 60 mg/mL (153.68 mM)
Ethanol : 1 mg/mL


关键字: HDAC | HBI 8000 | CS055 | Histone deacetylases | Tucidinostat | Inhibitor | inhibit | HBI8000 | CS-055

相关产品: Elevenostat | HDAC8-IN-4 | BRD3308 | HDAC6-IN-18 | Quisinostat dihydrochloride | SIS17 | Homobutein | Givinostat hydrochloride monohydrate | UF010 | WT-161

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Anti-Pancreatic Cancer Compound Library | Reprogramming Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途