苯烯莫德 T4644

Product Introduction
Bioactivity


英文名: Tapinarof

描述: Tapinarof (Benvitimod) 是一种从发光杆菌中提取的天然产物，可消除炎症。它是芳烃受体 (AhR) 激动剂，EC50为 13 nM。

体外活性: Tapinarof activates the AhR pathway through direct binding. Tapinarof induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) in a dose-dependent way.

体内活性: Tapinarof acts through AhR to reduce inflammation in IMQ-treated mice. AhR-sufficient mice on a C57Bl/6 background exhibit a reduced clinical score after treatment with Tapinarof or 6-formylindolo(3,2-b)carbazole (FICZ). On the contrary, AhR KO mice do not respond to the anti-inflammatory effects of Tapinarof. FICZ is used as a comparator in these studies and yields similar results, with dramatically reduced inflammatory responses in wild-type, but not AhR KO mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (216.26 mM)


关键字: Inhibitor | AhR | WBI1001 | inhibit | WBI-1001 | GSK 2894512 | Tapinarof | Aryl Hydrocarbon Receptor | GSK-2894512

相关产品: 1,4-Chrysenequinone | StemRegenin 1 | Leflunomide | PDM11 | (-)-Perillaldehyde | Phortress | YL-109 | L-Kynurenine | D-Kynurenine | Mexiletine hydrochloride

相关库: Drug Repurposing Compound Library | Approved Drug Library | Transcription Factor-Targeted Compound Library | FDA-Approved & Pharmacopeia Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Apoptosis Compound Library | Nonsteroidal Anti-Inflammatory Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途