单甲基澳瑞他汀 D T4677

Product Introduction
Bioactivity


英文名: MMAD

描述: MMAD (Demethyldolastatin 10) 是一种有效的微管蛋白抑制剂，是抗体药物偶联物中的一种毒素有效载荷。

体外活性: MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. The site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity when compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction.

体内活性: The resulting antibody-drug conjugates (ADCs) exhibited complete tumor regression in rodents. They also have an improved toxicology profile in rats.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 24.5 mg/mL (31.77 mM)


关键字: inhibit | Demethyldolastatin-10 | Demethyldolastatin10 | MMAD | Monomethyl Dolastatin-10 | Inhibitor | Microtubule/Tubulin | ADC Payload | Monomethyl Dolastatin10 | ADC Cytotoxin

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相关库: Anti-Aging Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途