1,7-二甲基黄嘌呤 T4973

Product Introduction
Bioactivity


英文名: Paraxanthine

描述: Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。

体外活性: When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH+neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH+neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH+ cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 1mg/mL
DMSO : 5.5 mg/mL (30.53 mM)


关键字: inhibit | Inhibitor | Endogenous Metabolite | Paraxanthine

相关产品: ATP disodium salt | Ac-Ala-OH | (2R,3R)-Butane-2,3-diol | N-Glycolylneuraminic acid | Uridine 5′-triphosphate tris salt | PF-07208254 | Estrone | Deoxycholic acid | D-Glucose 6-phosphate sodium | Acetyl Coenzyme A trisodium

相关库: Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Natural Product Library for HTS | Gut Microbial Metabolite Library | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library

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