(+)-川白芷内酯 T4S1421

Product Introduction
Bioactivity


英文名: Praeruptorin B

描述: Praeruptorin B 是一种固醇调控元件结合蛋白(SREBPs)的抑制剂。

体外活性: Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B powerfully decreases SRE-luciferase activity in a dose-dependent manner. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantly down-regulates the expression of SREBP-1c and SREBP-2 [1]. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9 [2].

体内活性: The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle-treated mice, although they are still heavier than the chow diet-fed mice. More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar to lovastatin. In addition, compared with vehicle-treated mice, Praeruptorin B significantly lowers the level of TC and TG in the liver, comparable to lovastatin. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: inhibit | Fatty Acid Synthase (FASN) | Praeruptorin B | Inhibitor

相关产品: Ezetimibe | 1-HEXACOSANOL | PF 429242 | Fatostatin hydrobromide | Ezetimibe ketone | FGH10019

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