化合物 CD532 T50110

Product Introduction
Bioactivity


英文名: CD532

描述: CD532 是一种高效的 Aurora A 激酶抑制剂，IC50 值为 45 nM。CD532 可阻断 Aurora A 激酶活性，驱动 MYCN 降解，可以直接与 AURKA 相互作用并诱导整体构象转变。CD532 可用于研究癌症。

体外活性: In MYCN-amplified neuroblastoma cell lines SK-N-BE(2) and Kelly, CD532 (1-10000 nM; 72 h) exhibits cytotoxicity with EC50s of 223.2 nM and 146.7 nM, respectively[1].In SK-N-BE(2) cells, CD532 (0.1-1 μM; 24 h) causes a dose-dependent loss of MYCN protein[1].Furthermore, CD532 (1 μM; 6 h) prevents S-phase entry in SK-N-BE(2) cells[1].

体内活性: In mice with subcutaneous sonic hedgehog (SHH)-subtype medulloblastoma, CD532 (25 mg/kg; i.p. twice weekly for 3 weeks) decreases the tumor volume and increases survival[1].In MYCN-amplified neuroblastoma xenografts, CD532 (60 mg/kg; i.p. for 2 days) reduces the level of MYCN protein[1].CD532 (20 mg/kg; i.p.) in mice exhibits a serum half-life of ~1.5 hours and an AUC0-24 of 27 μM•h[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 200 mg/mL (382.76 mM)


关键字: 1 [4 ({4 [(5 cyclopentyl 1H pyrazol 3 yl)imino] 1,4 dihydropyrimidin 2 yl}amino)phenyl] 3 [3 (trifluoromethyl)phenyl]urea | CD532 | CD-532 | CD 532 | 1[4({4[(5cyclopentyl1Hpyrazol3yl)imino]1,4dihydropyrimidin2yl}amino)phenyl]3[3(trifluoromethyl)phenyl]urea

相关产品: CCT129202 | Aurora inhibitor 1 | Barasertib | ENMD-2076 | Aurora Kinases-IN-4 | Barasertib-HQPA | URMC-099 | MBM-55S | Danusertib | Reversine

相关库: Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途