醋酸戈那瑞林 T5015

Product Introduction
Bioactivity


英文名: Gonadorelin Acetate (33515-09-2 free base)

描述: Gonadorelin Acetate (33515-09-2 free base) (Luteinizing Hormone Releasing Hormone (LH-RH)) 是下丘脑神经肽，在控制生殖功能中起关键作用。

动物实验: Rat:Immature female Sprague-Dawley rats receive either 50 ng Luteinizing Hormone Releasing Hormone (LH-RH)/kg BW or 20 mg NMA/kg BW in a 10% dextrose, 0.9% NaCl solution, while controls receive only vehicle. After completion of the treatment, rats are examined daily for vaginal opening.

体外活性: Luteinizing Hormone Releasing Hormone (LH-RH), also called gonadotropin-releasing hormone (GnRH), is the primary link between the brain, the pituitary and gonadal function, and has a key role in vertebrate reproduction. The endocrine actions of Luteinizing Hormone Releasing Hormone (LH-RH) and its analogs are mediated by high-affinity membrane receptors for LHRH on pituitary gonadotrophs. LHRH is expressed,together with its receptors,in hormonerelated tumors such as prostate cancer,to act as a local autocrine/paracrine growth inhibitory factor. In prostate cancer cells,the LHRH receptor is coupled to the Gi-cAMP pathway to inhibit cell proliferation.

体内活性: Luteinizing Hormone Releasing Hormone treatment advances the timing of vaginal opening by 5 days, which is used as an initial indicator for the time of puberty.

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 10 mM


关键字: Gonadorelin Acetate (33515092 free base) | 33515-09-2 | 33515-09-2 free base | Gonadorelin Acetate (33515 09 2 free base) | Luteinizing Hormone Releasing Hormone | LH-RH

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相关库: Anti-COVID-19 Compound Library | Peptide Compound Library | Human Endogenous Metabolite Compound Library Plus | Endocrinology-Hormone Compound Library | Metabolism Compound Library | Target-Focused Phenotypic Screening Library | Preclinical Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途