盐酸Bobcat339 T5198

Product Introduction
Bioactivity


英文名: Bobcat339

描述: Bobcat339 是一种基于胞嘧啶的选择性TET 酶抑制剂，抑制TET1和TET2的IC50值分别为 33 和 73 μM。它可作为靶向 DNA 甲基化和基因转录新疗法的起点，用于表观遗传学领域研究。

体外活性: HT-22细胞经1% DMSO溶解的10 μM Bobcat339处理24小时后，进行裂解。与载体对照组相比，处理Bobcat339的细胞全球5hmC水平显著降低。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (151.14 mM)


关键字: DNA Methyltransferase | Cytosine-based,TET | Bobcat339 Hydrochloride | epigenetics | enzyme | Bobcat339 | Bobcat-339 | TET1,TET2 | Inhibitor | Bobcat 339 | DNA MTases | DNMTs | inhibit | Bobcat339

相关产品: CM-579 trihydrochloride (1846570-40-8 free base) | CM-579 | 5-Methyl-2'-deoxycytidine | Guadecitabine sodium | TFMB-(S)-2-HG | RG108 | CM-272 | γ-Oryzanol | Tetrahydrouridine | DC-05

相关库: Anti-Aging Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Stem Cell Differentiation Compound Library | Methylation Compound Library | NO PAINS Compound Library | Chromatin Modification Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途