丁硫氨酸-亚砜亚胺 T5371

Product Introduction
Bioactivity


英文名: L-BUTHIONINE-(S,R)-SULFOXIMINE

描述: L-Buthionine-(S,R)-sulfoximine 是一种细胞渗透性和不可逆的 γ-谷氨酰半胱氨酸合成酶抑制剂，通过消耗 GSH 诱导细胞中的氧化应激，可降低细胞内谷胱甘肽的水平，其对黑色素瘤、乳腺卵巢癌标本的 IC50值分别为1.9 μM、8.6 μM 和29 μM。

体外活性: IC50 values (microM) for L-buthionine-S,R-sulfoximine (BSO) on melanoma, breast and ovarian tumor specimens were 1.9, 8.6, and 29, respectively. The IC90 for melanoma was 25.5 microM, a level 20-fold lower than steady-state levels achieved clinically [1]. GSH loss induced by L-buthionine-S,R-sulfoximine (BSO) leads to overproduction of reactive oxygen species (ROS) and triggers apoptosis of MYCN-amplified neuroblastoma cells [2].

体内活性: Systemic BSO administration selectively altered GSH homeostasis and EAAT3 levels in the mice cerebellum. Intraperitoneal treatment of mice with 6?mmol/kg of BSO depleted GSH and GSSG in the liver at 2?h of treatment [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Insoluble
H2O : 10 mM


关键字: Ferroptosis | stress | GSH | Inhibitor | eye-spot | inhibit | oxidative | L-BUTHIONINE-SULFOXIMINE | glutamylcysteine | LBUTHIONINE(S,R)SULFOXIMINE | L BUTHIONINE (S,R) SULFOXIMINE | L-BSO | L-Buthionine sulfoximine | BSO

相关产品: D-glutamine | UAMC-3203 hydrochloride | Deferasirox | PD146176 | TBHQ | Troglitazone | PRIMA-1 | Butylhydroxyanisole | Siramesine hydrochloride | U-73122

相关库: HIF-1 Signaling Pathway Compound Library | Cell Cycle Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Ferroptosis Compound Library | Inhibitor Library | Apoptosis Compound Library | NO PAINS Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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