拉扎贝胺 T5470

Product Introduction
Bioactivity


英文名: LAZABEMIDE

描述: Lazabemide (Ro 19-6327) 是一种单胺氧化酶 B 的选择性的可逆抑制剂 ，但对 MAO-A 活性较低。它高浓度时具有抑制单胺摄取的作用，能够抑制去甲肾上腺素、血清素和多巴胺摄取，其IC50值分别为 86 μM、123 μM 和 >500 μM。它可用于研究帕金森和阿尔茨海默病。

体外活性: LAZABEMIDE is selective, high-affinity ligands for enzymes.?KD and Bmax values for 3H-Ro 41 1049 in rat cerebral cortex were 10.7 nM and 7.38 pmol/mg protein, respectively, and for 3H-Ro 19 6327 were 18.4 nM and 3.45 pmol/mg protein, respectively.?In accordance with their potencies as enzyme inhibitors, binding to MAO-A and MAO-B was competitively inhibited by clorgyline (IC50 = 1.4 nM) and L-deprenyl (selegiline;?IC50 = 8.0 nM), respectively[1].

体内活性: Lazabemide is a reversible inhibitor of monoamine oxidase B (MAO-B) with IC50 values of 0.48 and 1.5 μM measured in platelets of human subjects ages 19-36 and 60-78, respectively[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 34 mg/mL (170.31 mM)


关键字: parkinson | inhibit | LAZABEMIDE | MAO | radical generation | ichemia | Monoamine Oxidase | alzheimer′s | smoking cessation | Inhibitor | DOPAC | disease

相关产品: Rasagiline | Bifemelane hydrochloride | Toloxatone | Sennoside A | Lazabemide hydrochloride | Purpurin | Safinamide mesylate | Safinamide | (Z)-SU4312 | Obtusin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途