化合物PQR620 T5472

Product Introduction
Bioactivity


英文名: PQR620

描述: PQR620 是一种可透过血脑屏障的，具有口服活性的mTORC1/2选择性抑制剂。

体外活性: PQR620 is a potent and selective mTOR inhibitor, which induces >1000-fold selectivity towards mTOR over PI3Kα in enzymatic binding assays.?In A2058 melanoma cells PQR620 demonstrates inhibition of protein kinase B (pSer473) and ribosomal protein S6 (pSer235/236) phosphorylation with IC50 values of 0.2 μM and 0.1 μM, respectively.?PQR620 shows excellent selectivity over a wide panel of kinases, as well as excellent selectivity versus unrelated receptor enzymes and ion channels.?PQR620 demonstrates its potency to prevent cancer cell growth in an NTRC 44 cancer cell line panel, resulting in a 10log(IC50) of 2.86 (nM).

体内活性: PQR620的理化性质赋予了其良好的口服生物利用度和卓越的脑部渗透能力。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 6.4 mg/mL (14.37 mM)


关键字: mTOR | PQR-620 | PQR 620 | Mammalian target of Rapamycin | Inhibitor | inhibit | PQR620

相关产品: mTOR inhibitor 9e | 9,9'-Di-O-(E)-feruloylsecoisolariciresinol | Dactolisib | Torkinib | BGT226 | α-Hydroxyglutaric Acid Lithium | PI3K/mTOR Inhibitor-2 | Torin 2 | mTOR inhibitor-3 | Zeylenone

相关库: Anti-Liver Cancer Compound Library | Antidepressant Compound Library | Anti-Ovarian Cancer Compound Library | CNS-Penetrant Compound Library | Neural Regeneration Compound Library | Inhibitor Library | Kinase Inhibitor Library | Metabolism Compound Library | Anti-Pancreatic Cancer Compound Library | NO PAINS Compound Library

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