氯化血红素 T5515

Product Introduction
Bioactivity


英文名: Hemin

描述: Hemin (Hemin chloride) 是一种含有氯的含铁卟啉，一种血红素加氧酶 (HO)-1 诱导剂。Hemin 对卟啉病具有治疗活性，可以减少患者的血红素缺乏，从而通过生物化学反馈抑制 δ-氨基乙酰丙酸合成酶的活性。

细胞实验: In vitro effects of various statins and hemin, a heme oxygenase inducer, on cell proliferation were evaluated in PA-TU-8902, MiaPaCa-2 and BxPC-3 human pancreatic cancer cell lines. The effect of statins on heme oxygenase activity was assessed and heme oxygenase-silenced cells were used for pancreatic cancer cell proliferation studies. Cell death rate and reactive oxygen species production were measured in PA-TU-8902 cells, followed by evaluation of the effect of cerivastatin on GFP-K-Ras trafficking and expression of markers of invasiveness, osteopontin (SPP1) and SOX2[1].

体外活性: 方法：胰腺癌细胞 PA-TU-8902、BxPC-3 和 MiaPaCa-2 用 Hemin (30 µM) 处理 48 h，使用 CellTiter-Glo Luminescent Cell Viability Assay 检测细胞活力。结果：Hemin 对 PA-TU-8902、BxPC-3 和 MiaPaCa-2 细胞系的细胞增殖有显著影响，使细胞增殖分别降至 62±5%、51±3% 和 38±8%。[1]方法：星形胶质细胞培养物用 Hemin (25 µM) 处理 12-24 h，使用 colorimetric method 检测铁含量。结果：在与 Hemin 孵育后，培养的星形胶质细胞发生了铁积累。[2]

体内活性: 方法：为研究对肾损伤的作用，将 Hemin (100 µmol/kg) 腹腔注射给肾缺血再灌注的 BABL/c 小鼠。结果：Hemin 预处理促进 ERK1/2 磷酸化并增强肾小管恢复，从而防止进一步的肾损伤。[3]方法：为研究对胰岛素抵抗的作用，将 Hemin (50 µmol/kg) 腹腔注射给高脂饮食的 C57BL/6 小鼠，每天一次，持续四周。结果：Hemin 通过增加骨骼肌的胰岛素敏感性来防止高脂肪饮食诱导的胰岛素抵抗的发展。[4]

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : < 1mg/ml (insoluble）


关键字: Autophagy | Mitophagy | inhibit | Ferroptosis | Hemin Chloride | Inhibitor | Hemin | Mitochondrial Autophagy

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途