化合物IDF-11774 T5537

Product Introduction
Bioactivity


英文名: IDF-11774

描述: IDF-11774 是新型低氧诱导因子 α (HIFα)-1的抑制剂，其 IC50=3.65 μM。。

动物实验: When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model.

体外活性: IDF-11774 treatment suppressed angiogenesis of cancer cells by reducing the expression of HIF-1 target genes, reduced glucose uptake, thereby sensitizing cells to growth under low glucose conditions, and decreased the extracellular acidification rate (ECAR) and oxygen consumption rate of cancer cells.

体内活性: Luciferase activity and HIF-1α accumulation are strongly suppressed in the tumors of mice treated by oral administration of IDF-11774, compare with the control.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (162.82 mM)


关键字: inhibit | HIF-PH | IDF 11774 | Hypoxia-inducible factors | HIFs | IDF11774 | IDF-11774 | Inhibitor | HIF/HIF Prolyl-Hydroxylase

相关产品: PHD2-IN-1 | Amifostine trihydrate | Hydroxycitric acid tripotassium hydrate | PT2399 | Oltipraz | HIF-2α-IN-9 | HIF-2α-IN-4 | HIV-IN-7 | EHP-101 | TM6089

相关库: HIF-1 Signaling Pathway Compound Library | Glycometabolism Compound Library | Anti-Cancer Metabolism Compound Library | Angiogenesis related Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Metabolism Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途