氢化黄体酮 T5556

Product Introduction
Bioactivity


英文名: 5a-Pregnane-3,20-dione

描述: 5a-Pregnane-3,20-dione 是内源性的孕酮代谢物。

细胞实验: MCF-7 cells were grown without or with 5a-Pregnane-3,20-dione (10(-9)-10(-5) M), and the effects on cell and nuclear morphology, adhesion plaques, vinculin and actin expression, actin polymerization, and microfilament distribution were examined by immunohistochemistry, morphometry (using confocal microscopy and digital computer imaging analysis), and Western blotting.?Treatment of cells with 10(-9)-10(-6) M 5a-Pregnane-3,20-dione resulted in dose-dependent decreases in cell area, cell-to-cell contacts, and attachment to the substratum, and increases in variation in nuclear area.?These changes in the 5alphaP-treated cells were accompanied by decreases in vinculin-containing adhesion plaques, vinculin expression, polymerized actin stress fibers, and decreases in insoluble and increases in soluble actin fractions.

体外活性: the endogenous progesterone metabolite,5a-Pregnane-3,20-dione, may be involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5 mg/mL (15.80 mM)


关键字: Inhibitor | inhibit | 5a-Pregnane-3,20-dione | 5aPregnane3,20dione | Endogenous Metabolite | 5a Pregnane 3,20 dione

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相关库: Anti-Tumor Natural Product Library | Human Endogenous Metabolite Library | Human Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | Endocrinology-Hormone Compound Library | Mouse Metabolite Compound Library | RO5 Drug-like Natural Product Library | Bioactive Compound Library | Natural Product Library

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