白屈菜酸 T5558

Product Introduction
Bioactivity


英文名: Chelidonic acid

描述: Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质，用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂，Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。

动物实验: female BALB/c mice was Maintained 6-week-old under pathogen-free conditions.?Sensitized mice on days 1, 5, and 14 by intraperitoneal ?injection of 100 μg OVA emulsified in 20 mg aluminum hydroxide and we challenged mice with 1.5 mg OVA.?Chelidonic acid was administrated orally before intranasal .?OVA challenge for 10 days.?Nasal symptoms were evaluated by counting the number of nasal rubs that occurred in the 10 min after OVA. provocation at 10 days after challenge.

体内活性: Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice[3]. Chelidonic acid may attenuate allergic reactions by inhibiting caspase-1 activity.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4 mg/mL (21.72 mM)


关键字: gamma-Pyrone-2,6-dicarboxylic acid | Inhibitor | NF-κB | inhibit | Chelidonic acid | Caspase | Nuclear factor-κB | Nuclear factor-kappaB | r-Pyrone-2,6-dicarboxylic acid

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相关库: Anti-Aging Compound Library | Anti-Breast Cancer Compound Library | Anti-Liver Cancer Compound Library | Pyroptosis Compound Library | Anti-Lung Cancer Compound Library | Human Metabolite Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Bioactive Compound Library

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