甲氧滴滴涕,甲氧氯 T5627
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 72-43-5 | ¥159.00 | 询底价 |
500 mg | 72-43-5 | ¥2,210.00 | 询底价 |
10 mg | 72-43-5 | ¥223.00 | 询底价 |
25 mg | 72-43-5 | ¥392.00 | 询底价 |
1 mL | 72-43-5 | ¥151.00 | 询底价 |
50 mg | 72-43-5 | ¥581.00 | 询底价 |
200 mg | 72-43-5 | ¥1,300.00 | 询底价 |
100 mg | 72-43-5 | ¥870.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Methoxychlor
描述: Methoxychlor 是一种有机氯农药,被认为是一种内分泌干扰物,会影响不同细胞模型中的 Ca²⁺ 稳态和细胞活力。
细胞实验: Fura-2, a Ca2?-sensitive fluorescent dye, was applied to measure [Ca2?]i. Methoxychlor at concentrations of 0.1-1 μM caused a [Ca2?]i rise in a concentration-dependent manner. Removal of external Ca2? abolished methoxychlor's effect. Methoxychlor-induced Ca2? influx was confirmed by Mn2?-induced quench of fura-2 fluorescence. Methoxychlor-induced Ca2? entry was inhibited by nifedipine, econazole, SK&F96365, and protein kinase C modulators. Methoxychlor killed cells at concentrations of 10-130 μM in a concentration-dependent fashion. Chelation of cytosolic Ca2? with 1,2-bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid/AM (BAPTA/AM) did not prevent methoxychlor's cytotoxicity. Methoxychlor (10 and 50 μM) induced apoptosis concentration-dependently as determined by using Annexin V/propidium iodide staining
体外活性: 在HA59T细胞中,methoxychlor通过促进蛋白激酶C敏感的Ca2+可渗透通道入侵,引起[Ca2]i上升,而不引起Ca2从库存释放。Methoxychlor还引发了与[Ca2]i上升无关的凋亡。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 22.5 mg/mL (65.1 mM)
关键字: Methoxychlor
相关库: Bioactive Compounds Library Max | Human Metabolite Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途