球姜酮 T5712

Product Introduction
Bioactivity


英文名: zerumbone

描述: Zerumbone 是从Zingiber zerumbetSmith 的根茎中分离的一种单环倍半萜烯，可有效抑制Epstein-Barr 病毒的激活，IC50为 0.14 mM，具有抗癌、抗炎、抗氧化和抗增殖的作用。

动物实验: Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h.Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone.

体内活性: Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. LPS-induced expressions of proinflammatory mediators, iNOS and COX-2, were inhibited by zerumbone. In addition, NFκB activation and Akt phosphorylation were inhibited by zerumbone in LPS-induced ALI. Suggested that the protective mechanisms of zerumbone on endotoxin-induced ALI were via inhibition of Akt-NFκB activation.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 44 mg/mL (201.53 mM)


关键字: HSV | Herpes simplex virus | anti-proliferative | sesquiterpene | Epstein-Barr | virus | inhibit | Inhibitor | zerumbone | Monocyclic | anti-cancer | anti-inflammatory | antioxidant

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相关库: Terpene Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Macrocyclic Compound Library | Human Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Anti-virus Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | NO PAINS Compound Library | Anti-infective Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途