匙羹藤新苷元 T5743

Product Introduction
Bioactivity


英文名: Gymnemagenin

描述: Gymnemagenin 是一种分离自G. sylvestre 的三萜。 它具有抗病毒作用，对糖尿病和肥胖症具有潜在的研究价值。

动物实验: Diabetes was induced in overnight-fasted rats by intravenous injection of 200 mg/kg body weight streptozotocin using a 5% solution of freshly prepared streptozotocin in 0.1 M citrate buffer (pH 4.5). Rats in the normal group were injected with a 0.1 M citrate buffer (pH 4.5) solution alone. A total of 40 rats (20 STZ-treated diabetic rats, 20 normal rats) were fed a basal diet for 4 weeks. The rats were divided into four groups (10 rats/group): group 1 (control), rats were fed the basal diet alone; group 2 (G. sylvestre-fed), rats were fed the basal diet plus Gymnemagenin (100 mg/kg/bw/day); group 3 (STZ-treated), STZtreated rats were fed the basal diet alone; group 4 (STZ-treated?G. sylvestre-fed), STZ-treated rats were fed the basal diet plus Gymnemagenin (100 mg/kg/bw/day).

体内活性: Gymnemagenin exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. Gymnemagenin decreased to normal levels. The presence of the antihyperglycemic compounds gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. Gymnemagenin to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels.

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL (59.2 mM)


关键字: Inhibitor | Gymnema,sylvestre | Gymnemagenin | inhibit

相关产品: BMS-779788 | GSK2033 | Saikosaponin A | SR9243 | RGX-104 hydrochloride | 27-Hydroxycholesterol | Icariside E4 | Ethyl 2,4,6-trihydroxybenzoate | Gymnestrogenin | GSK3987

相关库: Selected Plant-Sourced Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Viral Compound Library | NO PAINS Compound Library

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