7-木糖甙-10-脱乙酰基紫杉醇 T5749

Product Introduction
Bioactivity


英文名: 10-Deacetyl-7-xylosyl paclitaxel

描述: 10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物，具有改进的药理特性和更高的水溶性，用于治疗癌症。

体外活性: 7-Xylosyl-10-deacetyltaxol induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1].

体内活性: 7-Xylosyl-10-deacetyltaxol is an active compound used in traditional Chinese medicine to treat cancer.7-Xylosyl-10-deacetyltaxol through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-Xylosyl-10-deacetyltaxol transport (16.3?±?6.3?×?10 (-6)?cm/s; n?=?3) suggests that the drug may still be effectively absorbed in the intestinal tract[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (26.48 mM)


关键字: inhibit | 10-Deacetyl-7-xylosyl paclitaxel | 10Deacetyl7xylosyl paclitaxel | Microtubule/Tubulin | ADC Payload | 10 Deacetyl 7 xylosyl paclitaxel | ADC Cytotoxin | Inhibitor

相关产品: Epothilone B | Benproperine phosphate | Tubulin inhibitor 24 | KX2-361 | Albendazole | T-1101 tosylate | Batabulin | Cabazitaxel | Sovilnesib | Sabizabulin

相关库: Anti-Tumor Natural Product Library | Microtubule-Targeted Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Saccharide and Glycoside Natural Product Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | NO PAINS Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途