卡瓦胡椒素C T5753
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 37308-75-1 | ¥2,870.00 | 询底价 |
1 mL | 37308-75-1 | ¥762.00 | 询底价 |
1 mg | 37308-75-1 | ¥283.00 | 询底价 |
2 mg | 37308-75-1 | ¥395.00 | 询底价 |
10 mg | 37308-75-1 | ¥1,060.00 | 询底价 |
100 mg | 37308-75-1 | ¥4,170.00 | 询底价 |
25 mg | 37308-75-1 | ¥1,930.00 | 询底价 |
5 mg | 37308-75-1 | ¥662.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Flavokawain C
描述: Flavokawain C 是存在卡瓦胡椒根中的一种天然查尔酮,具有发展成为治疗结肠腺癌的化疗药物的潜力。它对 HCT 116 细胞作用的 IC50值为 12.75 μM。
细胞实验: Cell viability of HT-29 cells was assessed by Sulforhodamine B assay after FKC treatment.?Induction of apoptosis was examined by established morphological and biochemical assays.?ROS generation was determined by dichlorofluorescein fluorescence staining, and superoxide dismutase activity was measured using the spectrophotometric method.?Western blotting was used to examine the changes in the protein levels[1].
体外活性: Flavokawain C (FKC) markedly decreased the cell viability of HT-29 cells and the cells showed dramatic changes in cellular and nuclear morphologies with typical apoptotic features.?The induction of apoptosis correlated well with the externalization of phosphatidylserine, DNA fragmentation, decreased mitochondrial membrane potential, activation of caspases, and PARP cleavage.?This was associated with an increase in reactive oxygen species and a decrease in SOD activity.?The protein levels of XIAP, c-IAP1, and c-IAP2 were downregulated, whereas the GADD153 was upregulated after FKC treatment.?FKC induced cell cycle arrest at the G1 and G2/M phases via upregulation of p21 and p27 in a p53-independent manner.??FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 25 mg/mL (83.25 mM)
关键字: Apoptosis | Flavokawain C | inhibit | Inhibitor
相关产品: Zinc Protoporphyrin | Isoliensinine | Gemcitabine hydrochloride | pimpinellin | L-SelenoMethionine | Ursonic Acid | Ginsenoside Rh2 | ODQ | PFK-158 | Pexidartinib
相关库: Anti-Tumor Natural Product Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Chinese Pharmacopoeia Natural Product Library | Human Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Traditional Chinese Medicine Monomer Library | Tibetan medicine Compound Library | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Bioactive Compound Library
卡瓦胡椒素C T5753信息由TargetMol中国为您提供,如您想了解更多关于卡瓦胡椒素C T5753报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途