竹红菌甲素 T5771
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 77029-83-5 | ¥447.00 | 询底价 |
5 mg | 77029-83-5 | ¥1,190.00 | 询底价 |
500 mg | 77029-83-5 | ¥15,300.00 | 询底价 |
25 mg | 77029-83-5 | ¥3,890.00 | 询底价 |
50 mg | 77029-83-5 | ¥5,570.00 | 询底价 |
10 mg | 77029-83-5 | ¥1,930.00 | 询底价 |
100 mg | 77029-83-5 | ¥7,690.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Hypocrellin A
描述: Hypocrellin A 是一种天然的PKC 抑制剂,具有光诱导的抗肿瘤、抗真菌和抗病毒活性,还对 MHC 限制性抗原呈递发挥免疫调节作用。
细胞实验: Cells were seeded in 96-well plates at a density of 1*10^4 cells in a final volume of 100 μl and maintained in DMEM medium at 37℃ ?.?After cells were treated with different concentrations of HA (5, 10, 20, 40, 80 μM), 20 μl 5 mg/ml MTT solution were added to each well and incubated for 4 h in the incubator.?Then 150 μl DMSO were added to each well to dissolve the pellet, keep it in the dark for 15 min, and dissolve the crystal completely.?Automatic microplate reader measured at 490 nm optical density (OD value).?The experiment was repeated three times.?For combination test, cells were treated with 20 μM Hypocrellin A?and different?concentrations of OA(25,50,100, 200 μM) .
体外活性: Treatment with Hypocrellin A(HA) resulted in a decrease in cell viability and migration in HCC cells.?Furthermore, ?HA decreased the YAP and TEAD protein levels of the Hippo pathway.?HA could potentiate OA's effect on HCC cells.?HA could inhibit the growth of HCC cells in darkness through Hippo-YAP signaling and HA combined with OA had a better effect than HA or OA alone.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 2.5 mg/mL (4.57 mM)
关键字: Bacterial | inhibit | Hypocrellin A | PKC | Inhibitor | Protein kinase C | Parasite
相关产品: CHIR-090 | MUT056399 | CHEMBL1380345 | 4-Hydroxyquinoline | D-Cycloserine | Vaborbactam ammonium salt | Ethylparaben | HPi1 | Resveratrol | TBAJ-587
相关库: Human Metabolite Library | Kinase Inhibitor Library | Inhibitor Library | Epigenetics Compound Library | Anti-Parasitic Compound Library | Anti-Cancer Active Compound Library | Natural Product Library for HTS | TGF-beta/Smad Compound Library | Microbial Natural Product Library | Antiparasitic Natural Product Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途