罗莎白素 T5783

Product Introduction
Bioactivity


英文名: Rosamultin

描述: Rosamultin 是从Potentilla anserina L 分离的 19 α-羟基型三萜。它抑制 HIV-1 蛋白酶，具有抗氧化、抗炎和镇痛作用。

激酶实验: A substrate, His-Lys-Ala-ArgVal-Leu-(pNO2-Phe)-Glu-Ala-Nle-Ser-NH2, Inc. For the HIV1 protease assay, the stock solution of the prepared enzyme was diluted. The extracts or compounds(Rosamultin) tested were dissolved in dimethyl sulfoxide (10% in the reaction mixture). A reaction mixture (5 uL) composed of 1 L of 50 uM sodium acetate (pH 5.0), 1 uL of a substrate solution, 1uL of the plant extract or compound solution, and 2 uL of HIV1 protease solution, was stirred, centrifuged, and then incubated at 37℃ for 1 hour in a microtube. A control reaction was performed under the same conditions without plant extract or compounds. The reaction was stopped by heating at 90 ℃ for 1 minute. Thirty-five microliters of autoclaved water was added into the reaction mixture, and an aliquot of 5 uL was analyzed by high-performance liquid chromatography (HPLC).

体外活性: 来自R. rugosa根部提取的Rosamultin，在100 microM浓度时，抑制HIV-1蛋白酶的活性达到53%。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mg/mL (15.36 mM)


关键字: inhibit | Inhibitor | HIV Protease | Protease | antioxidant | triterpenoid | oxidative stress injury | HIV-1 | Rosamultin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途