旋覆花内酯 T5793

Product Introduction
Bioactivity


英文名: Britannin

描述: Britannin 是分离于旋覆花的一种倍半萜内酯，可通过激活由 ROS 调节的 AMPK 来诱导肝癌细胞凋亡和自噬，具有抗增殖和抗炎活性。

体外活性: Britannin, a sesquiterpene lactone isolated from Asteraceae family, has antiproliferative activity on the MCF-7 and MDA-MB-468 human breast cancer cells. Annexin V/propidium iodide (PI) staining, Hoechst 33258 staining, and caspase-3/9 activity assay confirmed that britannin is able to induce apoptosis in MCF-7 and MDA-MB-468 cells. The expression of Bcl-2 was noticeably decreased in response to britannin treatment, while the expression of Bax protein was increased, which were positively correlated with elevated expression of p53. Moreover, britannin also increased reactive oxygen species (ROS) generation which in turn triggered the loss of mitochondrial transmembrane potential (ΔΨm) and the subsequent release of cytochrome c from mitochondria into cytosol.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (122.81 mM)


关键字: Inhibitor | inhibit | Autophagy | Britannin | Apoptosis

相关产品: Demethylzeylasteral | Chelidonine | Antitumor agent-113 | Ginkgetin | Lucidenic acid B | WYE-132 | FB23-2 | TAS6417 | Dehydrocrenatidine | Puerarin 6''-O-Xyloside

相关库: Terpene Natural Product Library | Anti-Cancer Compound Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Apoptosis Compound Library | Food as Medicine Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途