车前草苷D T5796

Product Introduction
Bioactivity


英文名: Plantainoside D

描述: Plantainoside D (Isoplantamajoside) 可以抑制 ACE ，IC50=2.17 mM。Plantainoside D 也是IKK-β抑制剂。

激酶实验: Ethanolic extract of the seeds of Plantago asiatica L. showed significant inhibitory activity of angiotensin-converting enzyme (ACE) determined by monitoring the transformation from a substrate hippuryl-histidyl-leucine (HHL) to the product hippuric acid (HA) in vitro using an UPLC-MS method. The bioguided fractionation of the extract resulted in the isolation of four ACE inhibitory active phenylpropanoid glycosides acteoside, isoacteoside, Plantainoside D, and plantamajoside with IC(50) values of 2.69 mM, 2.46 mM, 2.17 mM, and 2.47 mM, respectively. Their structures were elucidated through the analysis of NMR, UV, IR and MS data[1].

体外活性: Plantago asiatica L. and its major constituents(such as Plantainoside D) have ACE inhibitory activity in vitro. The identified compounds contribute to the angiotensin-converting enzyme-inhibitory activity of the extract[1].In vitro, Adriamycin(ADR) caused dose-dependent toxicity in H9c2 cardiac muscle cells. Pre-treatment of the cardiac muscle cells with Plantainoside D(PD) significantly reduced ADR-induced apoptosis of cardiac muscle cells. PD inhibited the ROS produced by ADR in the cardiac muscle cells. As well, PD increased GSH(glutathione), compared with ADR. In response to ADR, NF-kappaB was activated in H9c2 cells. However the treatment of PD reduced the activation of NF-kappaB.The NF-kappaB inhibitor, PDTC, inhibited the cytotoxic effect on ADR-induced apoptosis in cardiac muscle cells. IkappaBalpha-dominant negative plasmid-overexpression abrogated ADR-induced apoptosis in H9c2 cardiac muscle cells[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 10 mg/mL (15.6 mM)
DMSO : 10 mM


关键字: I kappa B kinase | Inhibitor | Plantainoside D | IKK | Angiotensin-converting Enzyme (ACE) | inhibit | IκB kinase

相关产品: L162441 | Acein acetate | Resorcinolnaphthalein | Sparsentan | Pivalopril | Pomisartan 2HCl | Eprosartan Mesylate | Araloside A | Zabicipril | Vicenin 2

相关库: Oxidation-Reduction Compound Library | Selected Plant-Sourced Compound Library | Membrane Protein-targeted Compound Library | Chinese Pharmacopoeia Natural Product Library | Ferroptosis Compound Library | Kinase Inhibitor Library | Inhibitor Library | Epigenetics Compound Library | Traditional Chinese Medicine Monomer Library | TGF-beta/Smad Compound Library

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