盐酸人血草碱 T5807

Product Introduction
Bioactivity


英文名: Stylopine hydrochloride

描述: Stylopine hydrochloride 是一种生物碱类化合物，从紫堇属之植物块茎中分离得到，具有抗炎症和抗寄生虫作用。

体外活性: Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries.?Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.?The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner.?Suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions.?These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5 mg/mL (13.89 mM)


关键字: alkaloid | (±)-Stylopine | Corydalis | Inhibitor | Tetrahydrocoptisine | anti-parasitic | inhibit | Stylopine hydrochloride | Stylopine Hydrochloride

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相关库: Anti-Aging Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Chinese Pharmacopoeia Natural Product Library | Anti-Colorectal Cancer Compound Library | Anti-Parasitic Compound Library | Traditional Chinese Medicine Monomer Library | Antiparasitic Natural Product Library | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library

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