水合氧化前胡素 T5808

Product Introduction
Bioactivity


英文名: (-)-Oxypeucedanin hydrate

描述: (-)-Oxypeucedanin hydrate 是一种呋喃香豆素衍生物，分离自Ducrosia anethifolia 中。

细胞实验: Pure compounds were isolated from the extract of aerial parts of the plant by chromatographic methods.Bioactivities were tested on multidrug resistant and sensitive mouse T-lymphoma cell lines.The inhibition of the cancer MDR efflux pump ABCB1 was evaluated by flow cytometry (at 2 and 20 μM).A checkerboard microplate method was applied to study the interactions of furocoumarins and doxorubicin.Toxicity was studied using normal murine NIH/3T3 fibroblasts.

体外活性: Oxypeucedanin exhibited marginal toxicity on normal fibroblast cells and sensitive parental mouse lymphoma cells;?furthermore, they were less toxic on multidrug resistant lymphoma cells.? Oxypeucedanin showed moderate MDR reversing activity.?In the checkerboard assay, oxypeucedanin and heraclenin showed slight synergistic effect with doxorubicin.?These compounds might improve the cytotoxic effect of the standard chemotherapeutic drug doxorubicin.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (180.75 mM)


关键字: cytotoxic | ( ) Oxypeucedanin hydrate | cell | tumor | inhibit | Inhibitor | ()Oxypeucedanin hydrate | antiproliferative | cancer | Oxypeucedanin Hydrate

相关库: Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Traditional Chinese Medicine Monomer Library | Anti-COVID-19 Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Tibetan medicine Compound Library | Traditional Mongolian Medicine Compound Library | RO5 Drug-like Natural Product Library | Bioactive Compound Library

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