甲磺酸溴隐亭 T5842

Product Introduction
Bioactivity


英文名: Bromocriptine mesylate

描述: Bromocriptine mesylate (CB-154) 是一种有效的多巴胺受体激动剂，以最高的亲和力结合 D2 受体，Ki 为 2.5 nM。

体外活性: The ergot alkaloid bromocriptine (BKT) was found to act as a strong inhibitor of purified neuronal nitric oxide synthase (NOS) (IC50 = 10 +/- 2 microM) whereas it was poorly active towards inducible macrophage NOS (IC50 > 100 microM). BKT affects the activation of NOS by calmodulin, as it not only inhibits L-arginine oxidation to NO and L-citrulline but also NADPH oxidation and calmodulin-dependent cytochrome c reduction catalyzed by neuronal NOS. These results suggest that BKT could exert some of its therapeutic effects by interfering with the NOS-dependent formation of nitric oxide and/or superoxide ion in various tissues.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL (39.96 mM)


关键字: Dopamine Receptor | Autophagy | Bromocriptine Mesylate | Bromocriptine | CB 154 | Inhibitor | inhibit | Bromocriptine mesylate | CB154

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