奥美沙坦 T5964
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 144689-24-7 | ¥413.00 | 询底价 |
1 mL | 144689-24-7 | ¥455.00 | 询底价 |
50 mg | 144689-24-7 | ¥663.00 | 询底价 |
100 mg | 144689-24-7 | ¥1,080.00 | 询底价 |
500 mg | 144689-24-7 | ¥2,680.00 | 询底价 |
10 mg | 144689-24-7 | ¥258.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Olmesartan
描述: Olmesartan (RNH 6270) 是一种血管紧张素 II 受体 (AT1R) 拮抗剂,常用于研究高血压。
动物实验: In a randomized, double-blind, multicenter, controlled trial, Assigned 4447 patients with type 2 diabetes to receive olmesartan (at a dose of 40 mg once daily) or placebo for a median of 3.2 years.?Additional antihypertensive drugs (except angiotensin-converting-enzyme inhibitors or ARBs) were used as needed to lower blood pressure to less than 130/80 mm Hg. The primary outcome was the time to the first onset of microalbuminuria.?The times to the onset of renal and cardiovascular events were analyzed as secondary end points[1].
体内活性: The target blood pressure (<130/80 mm Hg) was achieved in nearly 80% of the patients taking olmesartan and 71% taking placebo;?blood pressure measured in the clinic was lower by 3.1/1.9 mm Hg in the olmesartan group than in the placebo group.?Microalbuminuria developed in 8.2% of the patients in the olmesartan group (178 of 2160 patients who could be evaluated) and 9.8% in the placebo group (210 of 2139);?the time to the onset of microalbuminuria was increased by 23% with olmesartan (hazard ratio for onset of microalbuminuria, 0.77;?95% confidence interval, 0.63 to 0.94;?P=0.01).?The serum creatinine level doubled in 1% of the patients in each group.?Slightly fewer patients in the olmesartan group than in the placebo group had nonfatal cardiovascular events--81 of 2232 patients (3.6%) as compared with 91 of 2215 patients (4.1%) (P=0.37)--but a greater number had fatal cardiovascular events--15 patients (0.7%) as compared with 3 patients (0.1%) (P=0.01),?a difference that was attributable in part to a higher rate of death from cardiovascular causes in the olmesartan group than in the placebo group among patients with preexisting coronary heart disease (11 of 564 patients [2.0%] vs. 1 of 540 [0.2%], P=0.02)[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 6.25 mg/mL (14 mM)
关键字: Inhibitor | Angiotensin Receptor | RNH6270 | Olmesartan | CS-088 | CS088 | RNH-6270 | inhibit
相关产品: Nitrosoglutathione | TRV-120027 acetate (1234510-46-3 free base) | Fimasartan | Perindopril erbumine | L162389 | VTP-27999 | Imidaprilate | Cilazapril Monohydrate | Captopril | Quinapril hydrochloride
相关库: Drug Repurposing Compound Library | FDA-Approved & Pharmacopeia Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Diabetic Compound Library | Orally Active Compound Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途