葫芦素 E T5S1467

Product Introduction
Bioactivity


英文名: Cucurbitacin E

描述: Cucurbitacin E 是从黄瓜的攀缘茎中分离得到的一种天然产物。它显着抑制细胞周期蛋白B1/CDC2复合物的活性，具有预防神经变性，具有强效的抗增殖、抗肿瘤、抗炎和镇痛作用行动。

体外活性: the anti-proliferation and cell cycle G2/M arrest induced by Cucurbitacin E (CuE)?in CRC cells.?MPM-2 flow cytometry tests show that CuE-treated cells accumulated in metaphase (CuE 2.5-7.5 μM).?CuE produced G2/M arrest as well as the downregulation of CDC2 and cyclin B1 expression and dissociation.?Both effects increased proportionally with the dose of CuE;?however, the inhibition of proliferation, arrest of mitosis, production of reactive oxygen species (ROS), and loss of mitochondrial membrane potential (ΔΨm) were found to be dependent on the quantity of CuE used to treat the cancer cells.?In addition, cell cycle arrest in treated cells coincided with the activation of the gene GADD45(α, β, γ).?Incubation with CuE resulted in the binding of GADD45γ to CDC2, which suggests that the delay in CuE-induced mitosis is regulated by the overexpression of GADD45γ.?CuE may have antitumor activities in established CRC[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (98.8 mM)


关键字: α-Elaterin | Autophagy | Cyclin dependent kinase | inhibit | α-Elaterine | CDK | Inhibitor | Cucurbitacin E

相关产品: WAY-322243 | BGG463 | JNJ-7706621 | CAF-382 | BS194 | (R)​-​CR8 | Lerociclib | CDK9-IN-8 | PNU112455A hydrochloride | BX795

相关库: Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Pancreatic Cancer Compound Library | Autophagy Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途