异鼠李素-3-O-葡萄糖苷 T5S1988

Product Introduction
Bioactivity


英文名: Isorhamnetin-3-O-glucoside

描述: Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) 是一种天然化合物，广泛存在于蔬菜和水稻中，经消化后可在肠道菌群中代谢。

体外活性: The inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated. METHODS AND RESULTS:The various fractions from the MeOH extract of S. herbacea were tested for their effects on RLAR in vitro. Among them, the EtOAc fraction was found to exhibit a potent RLAR inhibition (IC(50)=0.75 microg/ml), from which an active principle as a potent AR inhibitor was isolated and its chemical structure was elucidated as Isorhamnetin-3-O-beta-D-Glucoside (1) by spectral analysis. Compound 1 exhibited a potent RLAR inhibition in vitro, its IC(50) being 1.4 microM. Compound 1, when administered orally at 25 mg/kg in streptozotocin (STZ)-induced diabetic rats, caused not only a significant inhibition of serum glucose concentration but also sorbitol accumulation in the lenses, red blood cells (RBC), and sciatic nerves. CONCLUSIONS:These results indicate that compound 1 from S. herbacea is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (522.58 mM)


关键字: Inhibitor | inhibit | Isorhamnetin3Oglucoside | Isorhamnetin 3 O glucoside | Isorhamnetin-3-O-b-D-Glucoside | Isorhamnetin-3-O-β-D-Glucoside | Isorhamnetin-3-O-glucoside

相关库: Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Flavonoid Natural Product Library | NO PAINS Compound Library

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