化合物HS-243 T60012

Product Introduction
Bioactivity


英文名: HS-243

描述: HS-243 是 IRAK-4 和 IRAK-1 的抑制剂，IC50 分别为 20 和 24 nM。 HS-243 显示出抗炎和抗癌活性。

体外活性: HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC50 of 0.5 μM. HS-243 (0-10 μM) inhibits cell survival by 21% for AN3-CA pancreatic cancer cells, and 13% for SKOV-3 ovarian cancer cells. HS-243 (10 μM) potently reduces the pro-inflammatory response of RA cells and macrophages and significantly reduces the secretion of 15 cytokines, including IL-8, CD14, GRO-α, MIP-1a, MIP-3a, uPAR, Osteopontin, MMP-9, MCP-1, I-TAC, TIM-3, IP-10, GDF-15, and RANTES[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mg/mL (30.83 mM)


关键字: RA-FLSs | Inhibitor | immunology | autoimmune disease | inhibit | Interleukin-1 receptor associated kinase | tumor necrosis factor | HS243 | interleukin | IRAK | rheumatoid arthritis | H460 | IL-1R associated kinase | THP-1 | Cyclin dependent kinase | HS 243 | AN3-CA | HS-243 | TNF | anti-inflammatory | CDK

相关产品: IRAK4-IN-4 | IRAK inhibitor 1 | IRAK4-IN-20 | IRAK4-IN-27 | IRAK inhibitor 2 | IRAK inhibitor 6 | IRAK4-IN-25 | IRAK-1-4 Inhibitor I | AS-2444697 | AZ1495

相关库: Anti-Prostate Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Active Compound Library

化合物HS-243 T60012信息由TargetMol中国为您提供，如您想了解更多关于化合物HS-243 T60012报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途