化合物 (Rac)-Indoximod T60266
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 26988-72-7 | ¥121.00 | 询底价 |
5 mg | 26988-72-7 | ¥173.00 | 询底价 |
Product Introduction
Bioactivity
英文名: (Rac)-Indoximod
描述: (Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL. Moreover, this co-treatment effectively improves cardiac fibrosis[1].
体外活性: (Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death irrespective of tryptophan depletion [1]. Cell Viability Assay [1] Cell Line: Human cardiac myofibroblasts (hCMs) Concentration: 0.5 mM Incubation Time: 3 days Result: Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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