化合物 Chloropyramine T60590

Product Introduction
Bioactivity


英文名: Chloropyramine

描述: Chloropyramine 是竞争性可逆 H1 受体拮抗剂，可用于过敏性疾病的研究，例如结膜炎和支气管哮喘。Chloropyramine 表现出抗乳腺癌活性。

体外活性: Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines [1]. Western Blot Analysis [1] Cell Line: Breast cancer cell lines Concentration: 25 or 50 μM Incubation Time: 24 h Result: Increased SASH1 expression in breast cancer cell lines. Apoptosis Analysis [1] Cell Line: T47D, MDA-MB-231 and BT-54 cells Concentration: 50 μM Incubation Time: 48 h Result: Induced apoptosis in breast cancer cell lines.

体内活性: Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats [2]. Animal Model: Rats [2] Dosage: 10 mg/kg Administration: Intraperitoneal Result: Reduced histamine-induced hypothermia.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途