化合物JNJ-1289 T60738

Product Introduction
Bioactivity


英文名: JNJ-1289

描述: JNJ-1289 是一种具有选择性、有效性和竞争性人精胺氧化酶 (hSMOX) 抑制剂，IC50 值为 50 nM。JNJ-1289 具有潜在的抗癌和抗炎活性，可用于研究多胺分解代谢类疾病。

体外活性: In a time-dependent manner, JNJ-1289 inhibits hSMOX activity, with assessments at 0 and 2 hours[1].Initially, JNJ-1289 forms a weak complex with hSMOX, characterized by an apparent Ki value of 1.4 μM. Subsequently, a relatively slow protein isomerization occurs, leading to the formation of the final tightly bound inhibitor-enzyme complex[1].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (162.15 mM)


相关产品: Sonidegib diphosphate | Sonidegib | Halcinonide | DY131 | Purmorphamine | MRT-14 | GI-560192 | 20(S)-Hydroxycholesterol | Jervine | SANT-1

相关库: Inhibitor Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途